What's the Difference between CBD Oil and Hemp Oil? It wasn’t until the last year or two that CBD oil became all the rage, but most likely you’ve heard of hemp. In the last decade, hemp products have been stocked all over the natural food store shelves and sold as a food and beauty product that has magical health benefits. Marketing aside, hemp really is magic. It has so many industrial and practical uses, but also serves as a nutritional food and is where CBD comes from. You can do so much with this extraordinary plant. However, when you look at CBD products on the store shelf, it can be confusing parsing through all the buzz words and marketing. CBD products aren’t regulated as of yet, so there are no standards by which companies are held to, making it even more challenging to choose a CBD product for your needs. This article sheds some light on the differences between hemp oil and CBD oil to end any confusion you may have. What Is Hemp? Hemp has a long history dating back 10,000 years. It is a varietal that comes from the Cannabis Sativa family of plants —making hemp a relative of marijuana. For decades, this close relationship caused the average person to confuse hemp and marijuana when in fact they are very different. For unlike marijuana, hemp was used for building materials, rope, clothing, and fuel before science discovered hemp seeds were high in omega-3 and -6 — making them nutritious and great for health. It wasn’t until the Farm Bill in 2014 and 2018 that hemp was allowed to be grown in the United States. Most hemp products sold in the US were manufactured in Canada or the UK. Now that regulations have loosened, more farmers are growing organic hemp. We are proud that our CBD comes from organic hemp grown in Colorado. Hemp oil, or hemp seed oil, comes from the seeds of the hemp plant and has no CBD or THC. It is similar to olive oil in that you should store it out of the direct sun and it is not a high heat cooking oil. Hemp seeds are considered a nutritious superfood because they are a “complete protein” with an excellent amino acid profile comparable to meat, and 50-70% more protein than chia or flax. One ounce of hemp seeds can provide ten grams of protein and much of your daily vitamin E needs, not to mention a ton of fibre, vitamins, and minerals. But if you are trying to get the wellbeing benefits that we know CBD can bring, hemp seeds and oil are not going to provide it. Where Does CBD Come From? We find the most cannabidiol (CBD) in hemp plants, which naturally are very low in THC —the compound in marijuana that gets you high. Marijuana, on the other hand, is grown for its psychedelic properties because of its high THC level — but it is also low in CBD. It is also quite different from hemp, anatomically and biologically speaking. You can also see the difference by looking at the plants. The main difference between hemp oil and CBD oil is that CBD is extracted from the whole plant — stalk, flower buds, and leaves — not just the seeds. The resulting CBD oil is used to make the CBD products you find today. Confusion between the two arises because CBD oil is mixed with a carrier oil — and this is often hemp oil. So your favourite CBD oil may say hemp oil on the bottle. Hopefully, this clears up in confusion you have between CBD oil and hemp oil. If you have any questions feel free to contact our customer service team and we are happy to help. CBD Hemporium is your one-stop shop for high quality, lab-tested CBD oil products. Sign up for our newsletter today and get 10% off your first order.
How Long Does CBD Last? Cannabidiol (CBD) is more popular than ever and is now available in many online and retail stores. People are looking for more ways to consume their favourite wellness product, which we cater for in abundance at CBD Hemporium. This natural plant-based product is one of the trendiest supplements for a good reason — many people are experiencing healthful benefits and an increase in their quality of life from using CBD. If you’ve just started on your CBD journey, you might be wondering how long CBD stays in your system and how long the effects will last. Many factors affect this and everyone reacts differently to CBD products. Some people will feel the effects more quickly with vaping or CBD tinctures, while some like to use a combination of products to get their desired results. Keep in mind that each type of CBD product has different absorption rates — CBD usage guidelines vary, and aspects like your BMI, diet, lifestyle, metabolism and genetics all influence how long CBD will last in your body and how fast you will feel the effects of CBD. How Fast Will You React to CBD? To figure out how fast your body will react and how long it stores CBD, you first have to consider bioavailability. When you consume a drug, substance or compound, your body only processes a small percentage of it because much of it is lost to first-pass elimination. Only a certain amount will hit your bloodstream and cause a reaction in the body. Research shows that you can absorb about 35% of the CBD in any given product, but, again, this varies according to many factors. When you consume CBD, it will travel through the body in different ways, depending on the method of consumption. Some people note that they feel CBD the fastest when they vape liquid because it bypasses the digestive system and hits the bloodstream faster. Many prefer the ease and convenience of taking CBD oil in a tincture or spray, which is a great way to have a noticeable reaction that isn’t as strong and rapid as vaping. It’s important to experiment with different methods of consumption to find what works for you. How Long Does CBD Stay in the Body? After it hits your bloodstream, CBD is processed by the liver and either makes its way out of your body through the digestive tract as waste or is stored in fat cells. This means that most of the CBD in a particular product is excreted through your stool within a day or two after your first dose. Research is ongoing, but based on early data, we can provide a guideline on how long CBD stays in the body. How long you use CBD for and if you are using it on a regular basis or sporadically will also affect how long it remains in your body — in essence, the more often you consume cannabinoids, the longer it will take to pass out of the body. Single use — Up to three days Moderate use — Three to five days Repeated and frequent use — Up to ten days and possibly longer However, these are rough estimates that come with serious caveats. For one, they are based on limited research on the half-life of CBD. In pharmacology, the term “half-life” is used to denote the amount of time it takes for a substance to decrease by half through elimination. This is important because the half-life will determine how often you take a drug. A 2016 review paper published by the journal Cannabis and Cannabinoid Research found that the average half-life of the cannabinoid tested was between 27 and 35 hours following a single dose. Another study found CBD used regularly for six consecutive weeks had a half-life of two to five days. If these small studies hold true for a larger population, the amount of CBD in your system will fall by half in just over a day to up to five days, depending on usage. How Body Weight and BMI Affects CBD Absorption Your body weight and Body Mass Index (BMI) could affect how fast you absorb and eliminate CBD. Since CBD is a fat-soluble molecule, it tends to build up in fat stores. Someone with a higher body weight may feel the effects of CBD longer than someone with a fast metabolism and lower body weight. More research is needed to determine exactly how CBD is absorbed and stored, but we can look at other scientific studies on drug absorption to understand this concept. How Lifestyle Affects CBD Absorption Your lifestyle choices will affect everything in your life, and how you absorb CBD is no different. Those with poor diets and sedentary lifestyles may hold CBD in their body longer than those with an active lifestyle and a healthy diet high in fibre. On the other hand, if you don’t typically take prescription or over-the-counter drugs, you may feel the effects faster. Again, you’ll have to experiment with different CBD products and dosages to see which you prefer, as your unique biochemistry will affect how CBD is metabolised in the body. So as you can see, there is no definitive answer on how long CBD will last in the body or how it will affect you. Taking CBD as a food supplement is very much a process of trial and error — we suggest starting with a low dose and slowly increasing it until you find the optimal consumption level for you. Taking CBD-rich products to maintain wellbeing is an endeavour in personalised natural healthcare. We can’t recommend CBD enough, as the benefits can be immense. Don’t give up after just trying one product at one dose — continue to experiment to find your sweet spot. Now that you have a better understand of how long CBD lasts, are you looking to start your CBD journey? At CBD Hemporium, you’ll find the highest-quality, organic and lab-tested CBD oil products, along with the best customer service. Browse our products today.
Is CBD Safe and Are There Any Side Effects of Using CBD? You may have wandered onto our website looking for the best CBD oil for sale in the UK but have never tried CBD before. Or maybe you’ve learned about it recently and are curious if CBD is safe to use. In this article, we’ll answer this question and ease any worries you might have about using CBD products. The question of safety has many layers, but in simple terms, the answer is unequivocally yes — CBD is entirely safe to use. This is backed up by the World Health Organisation’s report on CBD. While we’ll summarise this report for you, we encourage everyone concerned about whether CBD is safe to read it themselves. This report is an unbiased WHO review of CBD, which confirms the benefits of what we at CBD Hemporium, in many ways, believe to be a miraculous plant compound (which can be further enhanced through whole plant full-spectrum extract). The important takeaways from this report include: Cannabidiol (CBD) is well tolerated with a good safety profile and any adverse reactions are likely due to drug interactions. To date, there is no evidence of recreational use or any public health-related problems with the use of pure CBD. CBD has low levels of toxicity. A recent study backed this up, stating that even a very high dose of 1,500 mg per day is well tolerated. Building up a tolerance to CBD is thus far not observed in those who use it regularly, so there is limited potential for abuse. Let’s ponder these bullet points for a moment. Contrast the above points with the vast majority of other substances and medications available to us from our health authorities. Can we say any of them meet all, if any, of these summarised points? We think not, but we’ll let you decide. Also contained within the WHO article — and a growing body of well researched published articles — are the potential applications of CBD for a multitude of wellness benefits. If you’ve been worried that CBD products might make you feel high or disoriented, keep in mind that our CBD is extracted from organic hemp plants and contains less than 0.2% of THC (the compound that gets you high). If you are curious about the difference between CBD and THC, reading more about the subject will help ease your mind. CBD is a non-psychoactive compound, so there are no harmful side effects when taking our CBD oil products. One point in the WHO report discusses the potential for CBD to be converted into THC. However, it’s important to know that this is only possible in a laboratory test tube. This does not happen when you consume CBD oil or CBD oil-based products, as it is biologically impossible. This is all good news for a fledgling industry in its infancy. Unfortunately, there are no set standards that all CBD companies are working toward, which makes it imperative that you buy CBD oil from a reputable company that adopts clearly stated high standards — not all CBD products are created equal. At CBD Hemporium, we take quality control seriously and set extremely high standards in everything we do. All our CBD products have been manufactured from USDA-certified organic hemp, which is an essential consideration when looking at the safety of the CBD products you buy. On top of this, all our CBD products are independently lab tested, not only for potency so that you can be certain of how much CBD is in each of our products but also to test the distillate we use in manufacture for terpene profile and contaminants (heavy metals and pesticides). We want to make sure we are selling the best organic CBD oil for sale so that you can be confident when purchasing from us. Our customers have 100% confidence in the quality, safety and efficacy of each of our products. That is our commitment to you. You can also find out what makes the best CBD oil by learning how CBD is made and how to identify a quality product, ask the correct questions of your supplier and know you are paying for a great product. Unfortunately, many companies are looking to capitalise on people’s misfortune and have no standards — nevermind quality control processes — in place. Whether the CBD product you buy is safe or not depends on which company you buy from. Not all companies have the exact high standards and quality control processes in place as we do at CBD Hemporium. If you are ready to start your CBD journey, you can be rest assured it is safe to use — as the WHO article outlines, along with many other scientific studies and research — although we encourage you to read up on CBD and drug interactions if you’re taking prescribed medication and to speak to your doctor before trying CBD. Looking to start your CBD journey? At CBD Hemporium, you’ll find the highest quality, organic and lab-tested CBD oil products, along with the best customer service. Browse our products today. https://gregorzorn.com/cbd-does-not-convert-to-thc-in-our-bodyor-does-it/
CBD Usage Guidelines Our CBD products are sold as food supplements only and are not to be used to diagnose, treat or cure any medical condition. We cannot give any advice or specific recommendations on dosage for using CBD products, but we can give you some general guidelines on taking our product as a food supplement. Below is some general advice that you may find useful to help determine which CBD product and dosage is right for you. There are many variables to consider when taking CBD — including your BMI, diet, lifestyle, metabolism, genetics, product consistency, delivery method and more — which make a universally set dosage amount of CBD impossible. While we wish we could give our customers a mathematical CBD usage calculator, it’s not that simple — rough estimates are about as good as it gets. It’s our hope that with the information we provide on our website, along with scientific research on the subject, you can make an informed decision for yourself regarding how to use CBD. Which CBD Product Should I Use? With these points in mind, we advise people who are new to CBD products to start their journey with the minimal suggested CBD amount for any product and gradually increase it, if necessary, until they achieve the desired results. You will hit your “sweet spot” where you will get the maximum benefit at whatever dose is right for you. This is very much a personal journey. Some customers may find that they get the biggest benefit by using a mix of products and delivery methods. But if you are just setting out on your CBD journey, we recommend starting with one product type (sublingual CBD oil drops or spray, for example), and then look to mix up the products you use. This means you won’t be taking more than you actually need, which will save you money, and you’ll also be able to better understand how different delivery methods affect you. There are four ways to consume CBD — oral, sublingual, inhalation, and topical. Every person will find that each way of consuming CBD affects them differently. There is evidence that suggests that taking CBD sublingually or inhaling CBD are the fastest ways to feel the effects, but you’ll want to experiment to find what works best for you. You can take CBD sublingually with a pure CBD oil tincture or spray. This method takes the concentrated CBD and mixes it with a carrier oil — this is the most popular way to use CBD. If using this method, we recommend holding the organic CBD oil under the tongue for around two minutes for maximum absorption. This allows the CBD to be absorbed by the mucous membranes inside your mouth. Using a CBD vape could bring you rapid results because the CBD is absorbed by the lungs and bypasses the digestive tract. Some people find this gives the fastest hit but has the shortest duration of effect. This method won’t be for everyone, so you may want to start with CBD oil first. The other two methods, oral and topical, also have their own benefits, so you may want to give these a try too. How Much CBD Should I Take? It’s a good practice to start with a low dosage and build slowly. Not only does this give your endocannabinoid system (ECS) time to adjust and respond to the benefits of CBD, but also: It reduces any unwanted biphasic effects. Biphasic means that high and low doses can produce opposite results. Contrary to what we might think — that taking a higher dose will get us our desired results quicker — the biphasic nature of CBD could induce exactly the opposite effects you are looking to achieve. You’ll never know if you can get the same results with a lower dose if you start too high. This also saves you money in the long run. It can help to avoid or minimise a herxheimer reaction, where your symptoms temporarily worsen. If this does happen, reduce your dose and drink plenty of water. CBD doesn’t necessarily work instantly. Depending how well your ECS responds, some people will get relief quickly, while for others, it can take several weeks to see significant results. It’s important to be patient and follow the directions that come with your chosen CBD product. Once you gauge the effects of your current dose, you can slowly adjust. Once you get desired result, it’s important to tweak only very slightly from this point. If you get no additional benefits, you may have passed your “sweet spot” and you should reduce your dosage to maintain the best effect. CBD has a therapeutic ceiling, which means that taking more beyond this point won’t give you any further benefits and will only result in unnecessary additional expense. The aim is to get maximum relief using the smallest dose possible. It is generally advised to leave a two-hour gap between taking CBD as a food supplement and any other medications that are processed by the P450 enzymes, as this allows them to metabolise individually. This includes over-the-counter drugs such as paracetamol, ibuprofen or similar. Beta blockers, blood pressure drugs, anticoagulants and any other medications that carry a grapefruit warning generally require a four-hour gap between taking these and consuming CBD as a food supplement. As we previously stated, if you are in any doubt, please consult your doctor before taking CBD products. Looking to start your CBD journey? At CBD Hemporium, you’ll find the highest quality, organic and lab-tested CBD products along with the best customer service. Browse our CBD products today.
How Is CBD Made and What Makes a Quality Product? CBD is all the rage, but not all products are created equal. Many retailers produce CBD products that are of poor quality, containing harmful ingredients and pesticides — and sometimes lie about the amount of CBD actually inside the product. This is why it’s important to buy the best CBD oil products from a company like CBD Hemporium. We use only the highest quality hemp-derived CBD from organic hemp farms in Colorado and lab test each product to make sure they are free from harmful ingredients. Where Does CBD Come From? Cannabidiol — or CBD — is a naturally occurring chemical compound found in the cannabis sativa plant. It’s extracted or derived from either variety of sativa — hemp or marijuana. The CBD products that are legal across the UK are hemp-derived and contain less than .2% THC (Tetrahydrocannabinol) by law. While hemp is naturally higher in CBD than THC, breeders can manipulate the plant to have virtually no THC. On the other hand, marijuana for recreational purposes is usually bred to be high in THC and low in CBD, because its consumers want to use it to get high. With hemp-derived CBD products, there is no way to get high or have the same side effects as marijuana because there’s very little THC in the product. It’s worth mentioning that there are medicinal products that are marijuana-derived that have a good amount of CBD. There is some evidence that this type of product has higher therapeutic value — but that they come with far more side effects because of the high THC levels. These types of products are only available with a prescription in the UK. More scientific research and studies on humans have been done with marijuana than with hemp-derived CBD, and evidence shows they work more efficiently together to treat certain conditions. Why Source Material Matters To start let’s consider the first and most important constituent — what is the source material used to manufacture our products? Our CBD comes from whole plant extractions from organically grown hemp. This means that the entire plant is used in the process. The vast majority of CBD products available for purchase in the UK are sourced from hemp that is grown abroad, primarily from EU approved hemp seed stock, but also from American hemp cultivars (strains). Through our companies intensive R&D phase of sampling and testing many CBD oil products, we chose CBD derived from American hemp as the base material for all our products. Equilibrium CBD products are free from genetically modified organisms (GMOs), pesticides or herbicides. We also batch test the distillate used to manufacture our oils to ensure they are free from contaminants such as heavy metals and pesticides. We then go a step further by testing the terpene profile. We do this so we can ensure the quality, safety and efficacy of all of our products for our customers. Do you know how safe your CBD products are in this regard? These are very important considerations when buying a product you are taking for its wellness properties because contaminants that accumulated in plant tissues from surrounding soil (or the use of pesticides and herbicides) will only be concentrated further as you move toward extraction of the CBD. How Is CBD Made? There are many ways to extract CBD from hemp. We use the CO2 extraction method, which uses a combination of pressurised carbon dioxide and temperature to extract CBD from the source material. This method is considered the “gold standard” way to extract CBD because it helps preserve more of the compound. CO2 extraction methods are classified into two categories — supercritical and subcritical extraction. At CBD Hemporium, all our products have been extracted via supercritical CO2 process. In simple terms, CO2 cannabis extraction uses pressurised carbon dioxide (CO2) to pull CBD (and other phytochemicals) from the plant. Supercritical extraction has many benefits including being safe, effective and producing a pure extract. Once our source material has been decarboxylated and undergone CO2 extraction, we are left with a crude extract, which can then be further refined to remove unwanted impurities to improve the efficacy of our products. The extract goes through many filtering processes and distillation before it’s made into the final product. It’s a long, lengthy process that requires expensive equipment — so this whole process is reflected in the price of the product. It’s important to note that after obtaining a solvent-free oil through a CO2 extraction and a winterisation and distillation refinement, most of the terpene properties are lost. That is why in all our products, the beneficial terpenes are re-introduced to create a true full spectrum extract. The CBD distillate used to manufacture our products has been homogenised to ensure complete uniformity of the oil for cannabinoid and terpene potency in solutions. This is important when reintroducing terpenes into the distillate. Unfortunately, as yet, there are no set standards in the fledgeling CBD industry. However, at CBD Hemporium, we see it as our duty to produce a quality product and we take safety standards seriously. To our knowledge, we are one of only a few companies whose products have been manufactured from a CBD distillate following all these steps. Looking to start your CBD journey? At CBD Hemporium, you’ll find the highest quality, organic and lab-tested CBD oil products, along with the best customer service. Browse our products today.
Our body’s endocannabinoid system was found to be directly involved in the processes that keep our bodies balanced day to day, including: appetite, pain sensation, mood, memory, immune system functions, and inflammation control. Essentially, the system helps to manage homeostasis, balancing our body’s natural conditions. This system is made up of receptors that are located in the brain and nervous systems throughout the body. The reason that (phyto) cannabinoids have effects within the body is, in large part, because we have an endocannabinoid system (ECS) that they can interact with. It’s important to remember that molecules like cannabinoids and other neurotransmitters rarely interact with only one receptor type; they often interact with many. The plant-based cannabinoid CBD illustrates this nicely, as it interacts with numerous receptor types in the brain. So, while plant cannabinoids may activate the same cannabinoid receptors as endocannabinoids, they will likely interact with several other receptors and therefore have distinct effects. CBD is also interesting because it can affect overall levels of endocannabinoids in the brain, referred to as “endocannabinoid tone.” CBD inhibits the FAAH enzyme, which breaks down anandamide. Thus, CBD can increase anandamide levels by preventing FAAH from breaking it down. The body creates its own cannabinoids, called endocannabinoids, to help support this regulatory system. CBD supplements these naturally created endocannabinoids to keep the receptors working at optimal capacity. Similar to how we use vitamin C to kick start our immune system, CBD acts as a kick starter to help the functions of the body’s central regulatory system, which is the ECS. Cannabidiol (CBD), a non-intoxicating component of the cannabis plant, has generated significant interest among scientists in recent years—but how CBD exerts its wellness impact on a molecular level is still being fully figured out. Cannabidiol is a pleiotropic substance in that it produces many effects through multiple molecular pathways. The scientific literature has identified more than 65 molecular targets of CBD. Although CBD has little binding affinity for either of the two cannabinoid receptors (CB1 and CB2), cannabidiol modulates several non-cannabinoid receptors and ion channels. CBD also acts through various receptor-independent pathways—for example, by delaying the “reuptake” of endogenous neurotransmitters (such as anandamide and adenosine) and by enhancing or inhibiting the binding action of certain G-protein coupled receptors. Here are some of the ways that CBD confers its manifold wellness benefits. Serotonin Receptors Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and King’s College in London have conducted pioneering research into CBD and the neural correlates of anxiety. At high concentrations, CBD directly activates the 5-HT1A (hydroxytryptamine) serotonin receptor. This G-coupled protein receptor is implicated in a range of biological and neurological processes.. 5-HT1A is a member of the family of 5-HT receptors, which are activated by the neurotransmitter serotonin. Found in both the central and peripheral nervous systems, 5-HT receptors trigger various intracellular cascades of chemical messages to produce either an excitatory or inhibitory response, depending on the chemical context of the message. CBDA [Cannabidiolic acid], the raw, unheated version of CBD that is present in the cannabis plant, also has a strong affinity for the 5-HT1A receptor (even more so than CBD). Vanilloid Receptors CBD directly interacts with various ion channels. CBD, for example, binds to TRPV1 receptors, which also function as ion channels. TRPV1 is known to mediate pain perception, inflammation and body temperature. TRPV is the technical abbreviation for “transient receptor potential cation channel subfamily V.” TRPV1 is one of several dozen TRP (pronounced “trip”) receptor variants or subfamilies that mediate the effects of a wide range of medicinal herbs. Scientists also refer to TRPV1 as a “vanilloid receptor,” named after the flavorful vanilla bean. Vanilla contains eugenol, an essential oil that has antiseptic and analgesic properties; it also helps to unclog blood vessels. Historically, the vanilla bean has been used as a folk cure for headaches. CBD binds to TRPV1, which can influence pain perception. Capsaicin—the pungent compound in hot chili peppers—activates the TRVP1 receptor. Anandamide, the endogenous cannabinoid, is also a TRPV1 agonist. GPR55—orphan receptors Whereas cannabidiol directly activates the 5-HT1A serotonin receptor and several TRPV ion channels, some studies indicate that CBD functions as an antagonist that blocks, or deactivates, another G protein-coupled receptor known as GPR55. GPR55 has been dubbed an “orphan receptor” because scientists are still not sure if it belongs to a larger family of receptors. GPR55 is widely expressed in the brain, especially in the cerebellum. It is involved in modulating blood pressure and bone density, among other physiological processes. GPR55 promotes osteoclast cell function, which facilitates bone reabsorption. Overactive GPR55 receptor signaling is associated with osteoporosis. GPR55, when activated, also promotes cancer cell proliferation, according to a 2010 study by researchers at the Chinese Academy of Sciences in Shanghai. This receptor is expressed in various types of cancer. CBD is a GPR55 antagonist. PPARs - nuclear receptors CBD also infers effects by activating PPARs [peroxisome proliferator activated receptors] that are situated on the surface of the cell’s nucleus. Activation of this receptor known as PPAR-gamma, has an anti-proliferative effect as well as an ability to induce tumor regression in human lung cancer cell lines. PPAR-gamma activation degrades amyloid-beta plaque. This is one of the reasons why cannabidiol, a PPAR-gamma agonist, may be a useful supplement for wellness. PPAR receptors also regulate genes that are involved in energy homeostasis, lipid uptake, insulin sensitivity, and other metabolic functions. CBD as a reuptake inhibitor How does CBD, an exogenous plant compound, get inside a human cell to bind to a nuclear receptor? First it has to pass through the cell membrane by hitching a ride with a fatty acid binding protein (FABP), which chaperones various lipid molecules into the cell’s interior. These intracellular transport molecules also escort, the endocannabinoids anandamide and 2AG, across the membrane to several targets within the cell. CBD modulates receptors on the surface of the nucleus, which regulate gene expression and mitochondrial activity. Cannabidiol, it turns out, has a strong affinity for three kinds of FABPs, and CBD competes with our endocannabinoids, which are fatty acids, for the same transport molecules. Once it is inside the cell, anandamide is broken down by FAAH [fatty acid amide hydrolase], a metabolic enzyme, as part of its natural molecular life cycle. But CBD interferes with this process by reducing anandamide’s access to FABP transport molecules and delaying endocannabinoid passage into the cell’s interior. According to a team of Stony Brook University scientists, CBD functions as an anandamide reuptake and breakdown inhibitor, thereby raising endocannabinoid levels in the brain’s synapses. Enhancing endocannabinod tone via reuptake inhibition may be a key mechanism whereby CBD confers huge wellness benefits. CBD as an allosteric modulator CBD also functions as an allosteric receptor modulator, which means that it can either enhance or inhibit how a receptor transmits a signal by changing the shape of the receptor. Australian scientists report that CBD acts as a “positive allosteric modulator” of the GABA-A receptor. In other words, CBD interacts with the GABA-A receptor in a way that enhances the receptor’s binding affinity for its principal endogenous agonist, gamma-Aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. The sedating effects of Valium and other Benzos are mediated by GABA receptor transmission. Canadian scientists have identified CBD as a “negative allosteric modulator” of the cannabinoid CB1 receptor, which is concentrated in the brain and central nervous system. While cannabidiol doesn’t bind to the CB1 receptor directly, CBD interacts allosterically with CB1 and changes the shape of the receptor, limiting other cannabinoids ability to bind with it.
What Is CBD? This versatile plant compound has been in the news a lot recently, and for a good reason. People all over the UK are touting CBD’s benefits, and research shows it may be helpful for treating many conditions and ailments. We find the research fascinating and have been fans of plant medicine for years, especially after watching a family member have great success using medical cannabis. Could CBD be the next big thing to improve health and wellbeing? Cannabidiol, or CBD, is one of more than 100 different cannabinoids naturally occurring chemical compounds in cannabis plants. These cannabinoids are what make cannabis a special plant with varied properties that can be used from a wellness perspective. CBD, along with THC, are cannabinoids that are being studied by scientists to see what potential these plants can have for us. Where Does CBD Come From? CBD comes from the Cannabis Sativa plant, which has two popular varieties — marijuana and hemp. These two varieties are different not only anatomically and biologically but also in their uses. One of the most critical differences between hemp and marijuana is that each contains varying amounts of the cannabinoids THC and CBD. CBD and THC are present in both varieties of the cannabis plant, but the CBD sold in our store is produced and extracted from hemp. The hemp plant has a long and bumpy history dating back to 8000 BC when it was first discovered in Asia. It has many industrial uses and can be used to make paper, building materials and rope, be converted into fuel and more. Hemp is cultivated to be high in CBD but low in its sister cannabinoid THC — this is what makes you high when smoking or consuming marijuana. One of the most crucial qualities of CBD from the wellness and legal perspective is the absence of psychoactivity. In layperson’s terms, cannabidiol is non-intoxicating and not addictive, and products made from hemp-derived CBD that are low in THC are legal across the US, Canada, the UK, and most of the EU. The process of extracting CBD from hemp is a fascinating and complicated process. It takes many steps, and this is reflected in the price of the products. Rest assured that our CBD comes from USDA-certified organic hemp, which produces a higher-quality product than you can find on other websites and in high street shops. So, CBD Is Legal Then? We know it can be a little confusing with all the information that is available online, but, yes, CBD oil made from hemp is legal and safe to use in the UK because it contains less than 0.2% THC. CBD is not a controlled substance, and there are no harmful side effects of using CBD products. There is some evidence that it may react with prescription drugs, so if you want to start using CBD oil as part of a treatment plan, please seek guidance from your doctor beforehand on the right course of action. Scientific research on CBD is ongoing, and the Medicines and Healthcare products Regulatory Agency (MHRA) does not regulate it, so we can’t make specific recommendations. Everyone will have a different reaction to the different types of CBD products available, so we encourage you to start with a small dosage and track how you feel in a journal. We also recommend doing your research, as not all CBD products are the same. The CBD we use in our products is manufactured from organic hemp, and it’s very important for us to provide the highest quality products available. Safety and quality control is a top priority for us, and we are completely transparent on how our CBD is cultivated and manufactured. If you decide to try CBD, you’ll want to buy the best organic CBD oil for sale in the UK. If you’ve never given CBD a try, what are you waiting for? Join thousands of people who are enjoying a boost to their health and wellbeing. Looking to start your CBD journey? At CBD Hemporium, you’ll find the highest quality, organic and lab-tested CBD oil products, along with the best customer service. Browse our products today.